One of the first instructors at Wellesley College; first female faculty member at University of Rochester in 1902. Denio was born to John and Celinda (Weatherwax) Denio. She graduated from Mount Holyoke College in 1866. Denio then committed to a brief term as an instructor at Vassar College in Poughkeepsie, New Yrk. Joining Wellesley College in 1876, Denio taught German and Art, classes including, ‘Medieval German Literature,’ In 1883, she created the first inventory of art for the gallery at Wellesley College, the Catalogue of Works of Art Belonging to Wellesley College.